2-aminoethanol

A number of aliphatic amines have been identified as normal constituents of mammalian and human urine, including ethanolamine(1). Average excretion rate: men - 0.162 mg/kg per day; women - 0.492 mg/kg per day; cats 0.47 mg/kg per day; rats - 01.46 mg/kg per day; and rabbits - 1.0 mg/kg per day(1).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-aminoethanol, which has a vapor pressure of 0.404 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-aminoethanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.6 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Aminoethanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The Koc of 2-aminoethanol is estimated as 0.59(SRC), using a log Kow of -1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-aminoethanol is expected to have very high mobility in soil. Adsorption can be affected by the acidity of the soil(SRC). The pKa of 2-aminoethanol is 9.5(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

Monoethanolamine contained in wastewater from the ethylene manufacturing process is not toxic to aquatic microorganisms participating in biological wastewater treatment, and self-purification of reservoirs when in concn of 200, 300, 50, and 20 mg/L for protozoans, saprophyte bacteria, first phase nitrification bacteria, and second phase nitrification bacteria, respectively.

An estimated BCF of 3.2 was calculated in fish for 2-aminoethanol(SRC), using a log Kow of -1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). [

A pKa of 9.5(1) indicates 2-aminoethanol will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces and moist soil surfaces is not expected to be an important fate process(2). 2-Aminoethanol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 0.404 mm Hg(3).

The rate constant for the vapor-phase reaction of 2-aminoethanol with photochemically-produced hydroxyl radicals has been estimated as 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3.6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Aminoethanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 2-Aminoethanol does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

2-Aminoethanol was detected, not quantified in 24 Italian Cheeses(1). 2-Aminoethanol was detected in prune, plum, peach and nectarine juices at 1-6, 4, and 1 mg/L(2). 2-Aminoethanol has been identified as a meat volatile of chicken(3).

2-Aminoethanol has been identified in marine and freshwater algae(1).

The substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment in circumstances different to normal use.

A number of aliphatic amines have been identified as normal constituents of mammal and human urine, including ethanolamine(1).

2-Aminoethanol's production and use as a gas scrubbing agent, as a dispersing agent for agricultural chemicals, as a pharmaceutics aid, as a component in polishes, hair waving solutions, emulsifiers(1) and as a detergent used in dry cleaning and wool treatment(2) may result in its release to the environment through various waste streams(SRC). Its use in hydraulic fracturing(3) will result in its direct release to the environment.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,163,087 workers (328,648 of these were female) were potentially exposed to 2-aminoethanol in the US(1). Occupational exposure to 2-aminoethanol may occur through inhalation and dermal contact with this compound at workplaces where 2-aminoethanol is produced or used. Limited monitoring data indicate that the general population may be exposed to 2-aminoethanol via ingestion of food, use of tobacco products and dermal contact with consumer products containing 2-aminoethanol(SRC).

2-Aminoethanol is a component of tobacco(1,2).

2-Aminoethanol's production and use in hydraulic fracturing, as a gas scrubbing agent, as a dispersing agent for agricultural chemicals, as a pharmaceutics aid, as a component in polishes, hair waving solutions, emulsifiers and as a detergent used in dry cleaning and wool treatment may result in its release to the environment through various waste streams. 2-Aminoethanol has been identified as a constituents of mammalian and human urine. If released to air, a vapor pressure of 0.404 mm Hg at 25 °C indicates 2-aminoethanol will exist solely as a vapor in the atmosphere. Vapor-phase 2-aminoethanol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3.6 hours. 2-Aminoethanol does not conta...

irritation eyes, skin, respiratory system; drowsiness

... Here we investigated hair dye-induced dermatitis and hair loss using in vivo mouse model to uncover the causative ingredients. Commercially available hair dye products or combination of the ingredients of hair dye product were applied topically for 3 days on the dorsum of the female C57BL/6 mice and, dermatitis and hair loss were examined. The mice treated with hair dye products exhibited unequivocal signs of hair loss and dermatitis. To find out causative ingredients, combinations of the representative components of hair dye including reducing agents, the mixture of dye and monoethanolamine (MEA), ammonia, and hydrogen peroxide (H(2)O(2)) were applied and thereafter, hair loss and dermatitis were evaluated. All the groups treated with the combinations containing H(2)O(2) and neutra...

Eyes, skin, respiratory system, central nervous system

LC50 (mice) > 2,420mg/m3/2H

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

inhalation, ingestion, skin and/or eye contact

IDENTIFICATION AND USE: 2-Aminoethanol is a colorless, viscous liquid or solid (below 51 °F). It is not registered for current pesticide use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. The dual function groups, amino and hydroxyl, make it useful in cutting fluids and as intermediates in the production of surfactants, soaps, salts, corrosion control inhibitors, and in pharmaceutical and miscellaneous applications. 2-Aminoethanol and other amines appear to be potentially useful components of topical formulations used to decontaminate and protect the skin against chemical warfare agents. As a pharmaceutical adjuvant, it is used as a solvent for fats and oils, and in combination w...

No indication of carcinogenicity to humans (not listed by IARC).

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously ... . If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not respondi...