2,4′-DDT solution
Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1,1-trichloro- | 1,1,1-trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane | NSC33446 | NSC-33446 | D4K93Z1TBH | 2,4'-DDT D8 | NCGC00091035-01 | NCGC00091035-03 | 2,4'-DDT 100 microg/mL in Cyclohexane | SC
CAS789-02-6
Molecular formulaC14H9Cl5
Molar mass354.5 g/mol
Safe
o,p'-DDT can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to The National Institute for Occupational Safety and Health (NIOSH) and The Environmental Protection Agency (EPA).
Scientific Grain Officer - Dictionary Editorial Department, revised at:2026-10-19
Toxicity
ToxicitySymptoms
Acute signs of DDT poisoning include paresthesia after oral ingestion. Studies have shown that a mammal poisoned with DDT-type agents displays periodic persistent tremoring and/or convulsive seizures that are suggestive of repetitive discharges in neurons. These repetitive tremors and seizures can be initiated by tactile and auditory stimuli. (T10)
Treatment
Treatment of DDT exposure should be primarily directed towards decontamination and supportive care, as there is no specific antidote. The use of gastric lavage and activated charcoal for large ingestions may be effective. (L140)
Toxicity Data
LD50: 87 mg/kg (Oral, Rat) (L141) LD50: 1931 mg/kg (Dermal, Rat) (L141) LD50: 1500 mg/kg (Subcutaneous, Rat) (L141)
Health Effects
Exposure to DDT causes loss of weight and anorexia. DDT poisoning affects CNS function in humans, but pathologic changes are observed in the liver and reproductive organs. Hypertrophy of hepatocytes and subcellular organelles such as mitochondria, proliferation of smooth endoplasmic reticulum, centrolobular necrosis after exposure to high concentrations, and an increase in the incidence of hepatic tumors have been noted. (T10)
Exposure Routes
Oral (L85)
Toxicity Summary
DDT toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDT reduces potassium transport across the membrane. DDT inhibits inactivation of the porous channels through which sodium ions pass. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization, causing a state of hyperexcitability. DDT inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. DDT also inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. All these inhibited functions reduce the rate of d...
Carcinogen Classification
DDT is possibly carcinogenic to humans (Group 2B). (L2151)
